Skip 
Navigation Link
Medical Disorders
Resources
Basic InformationLookupsLatest News
Family History Questionnaire Ups Genetic Counseling for CRCBlood Test Can Detect GLUT1 Deficiency SyndromeWallpaper May Breed Toxins: StudyFish Eaters Report Less Rheumatoid Arthritis PainGuided Exercise May Help Chronic Fatigue Patients: Study2006 to 2013 Saw Increase in ER Use for Herpes ZosterNearly 60 Percent With Conjunctivitis Fill Antibiotic RxTissue Testing Can Spot Zika at Birth: CDCGuidelines Address Peri-Op Care in Rheumatic DiseaseZika-Bearing Mosquitoes More Widespread in U.S. Than ExpectedMarital Status Among Factors Tied to Gout Rx AdherenceMany Chronic Illnesses Linked to Suicide RiskVaccine Curbs High Cholesterol in MiceStudy Hints at Link Between Some Statins, Parkinson's RiskHydrotherapy Plus Conventional Drugs Beneficial in RAChronic Lyme Disease Treatments Tied to Serious Adverse EffectsOlder Age Needn't Be a Barrier to Herniated Disc SurgeryNon-Opioid Drug More Effective for Migraines: StudyHealth Tip: Managing Arthritis FatigueCertain Criteria May Be Better Than Others in RA Assessment20 Percent of Hospital Patients Have Side Effects From Abx RxRecreational Activity-Linked Facial Fractures Up in SeniorsUnusual Measles Outbreak Described in Ontario in Early 2015Seniors Get Good Results From Herniated Disc Surgery'Good' Donor Bacteria Can Last Long Term in Stool Transplant PatientsNovel Retinal Lesion Seen in Some Ebola SurvivorsHealth Tip: Recognizing Summer Allergy SymptomsAre You at Risk for Metabolic Syndrome?Antiplatelet Bleeding Risk Higher Than Expected for Older PatientsVideo Call May Be as Good as Doctor Visit for HeadacheCould Prefab Blood Vessels Revolutionize Root Canals?A Sufferer's Guide to Easin' Sneezin' SeasonHospitals Get Good News About Fighting Staph InfectionsCases of Legionnaires' Disease Reported in NYC, Las VegasOlive Oil, Ibuprofen May Have Synergistic EffectsObesity Prevalence Has Doubled in More Than 70 CountriesSeveral New Medications in the Pipeline to Prevent MigraineReview: Depression Screening As Inpatient Important, FeasibleVitamin B6 Linked to Increased Risk of Hip Fracture2 Billion Worldwide Are Obese or OverweightPatient's Education Level May Be Key to Heart RiskMeds Rooted in Ancient China May Help Heart: ReviewBats Harbor Viruses That Could Cause Outbreaks in HumansExperimental Zika Vaccine Protects Mice Against Virus: StudyGlobal Climate Change Could Cause Rise in Airway IrritationEqual Wound Complications for Staples, Suture in Obese WomenDepression Can Slow Hospital Patients' Recovery: StudyEven Your Bones Can Get Fat, Mouse Study SuggestsNew Drugs Show Promise as First to Prevent Migraine1 in 7 Americans Has Kidney Disease: CDC
Questions and AnswersLinksBook Reviews
Related Topics

Antiplatelet Bleeding Risk Higher Than Expected for Older Patients


HealthDay News
Updated: Jun 14th 2017

new article illustration

WEDNESDAY, June 14, 2017 (HealthDay News) -- Long-term daily aspirin use is linked to a higher-than-expected risk of disabling or fatal bleeding in patients aged 75 and over, according to a study published online June 13 in The Lancet.

Linxin Li, D.Phil., from the University of Oxford in the United Kingdom, and colleagues conducted a population-based cohort study involving patients with a first transient ischemic attack, ischemic stroke, or myocardial infarction treated with antiplatelet drugs (mostly aspirin) from 2002 to 2012, with follow-up to 2013.

The researchers found that during 13,509 patient-years of follow-up, 3,166 patients had 405 first bleeding events. There was no correlation for the risk of non-major bleeding with age; major bleeding increased with age (≥75 years: hazard ratio, 3.10), especially for fatal bleeding (hazard ratio, 5.53), which was sustained during follow-up. Similar trends were seen for major upper gastrointestinal bleeds (≥75 years: hazard ratio, 4.13), especially if the bleeding was disabling or fatal (hazard ratio, 10.26). To prevent one disabling or fatal upper gastrointestinal bleed over five years, the estimated number needed to treat (NNT) for routine proton pump inhibitor (PPI) use decreased from 338 for individuals younger than 65 years to 25 for individuals aged 85 years and older.

"Given that half of the major bleeds in patients aged 75 years or older were upper gastrointestinal, the estimated NNT for routine PPI use to prevent such bleeds is low, and co-prescription should be encouraged," the authors write.

One author disclosed financial ties to Bayer.

Abstract
Full Text
Editorial