Skip 
Navigation Link
Medical Disorders
Resources
Basic InformationLookupsLatest News
Zika Hijacks Pregnant Woman's Immune SystemHernia Patients May Need Fewer Opioids After Surgery, Study FindsHealth Tip: Prevent DehydrationTravel Tips for Contact Lens WearersHigher Odds of Infection With Reduced Kidney FunctionMost Ulcerative Colitis Patients Do Not Achieve Target RemissionOral Contraceptive Use Linked to Lower Rheumatoid Arthritis RiskKidney Disease May Boost Odds of InfectionZika May Not Last in Semen as Long as ThoughtVirtual House Calls for Speedy, Effective Parkinson's CareNearly 4 Million Worldwide Die Each Year From Asthma, COPDPowerful New Cholesterol Med Won't Harm Memory, Easing ConcernsDiverse Spectrum of Neurologic Syndromes Seen With ZikaExposure to Particulate Matter Linked to Metabolic AlterationsAir Purifiers May Help the Smog-Stressed Heart'Fat But Fit' a Myth?Statin Use Among Nursing Home Residents Varies SignificantlyZika Virus Tied to Neurological Woes in AdultsAn Expert's Guide to Preventing Food PoisoningHeart Risk Up if Hospitalized for Pneumonia or SepsisSinging May Be Good Medicine for Parkinson's PatientsCPAP Doesn't Alter Renal Function in Coexisting OSA, CVDWhen Stress Hormone Falters, Your Health May SufferKidney Disease May Boost Risk of Abnormal HeartbeatCertain Jobs Linked to Raised Risk of Rheumatoid ArthritisMidlife Vascular Risk Factors Tied to Increased Risk of DementiaHigher Risk of CVD Persists After Hospital Stay for Severe InfectionAntibiotic Doesn't Prevent Lung Complication After Stem Cell TransplantHealth Tip: One of Three Adults Gets ShinglesBlood Pressure Fluctuations Tied to Dementia Risk in StudyDecline in Kids' Ear Infections Linked to Pneumococcal VaccineFDA Approves Mavyret for Hepatitis CDoes Less Sleep Make You Less Healthy?Diabetes Drug Shows Promise Against Parkinson'sReview Suggests Benefits of Aerobic Exercise in FibromyalgiaNovel Procedure Improves Kidney Transplant SuccessABP 501, Adalimumab Biosimilar, Safe and Effective, for PsoriasisSimilar Defects ID'd for T2DM, Chronic Pancreatitis and DiabetesScientists Gain Insight Into AllergiesHealth Tip: Cooling a Heat RashKnow the Signs of ConcussionDo Your Pearly Whites Sometimes Cause You Pain?Rates of Inflammatory Bowel Disease Down in Rural AreasZika Probably Not Spread Through Saliva: StudyDrug for Kidney Disease Tied to Infection RiskGum Disease May Be Linked to Cancer Risk in Older WomenStent Surgery Could Benefit Select Glaucoma PatientsBlood Proteins Linked to Severity of Chronic Fatigue SyndromeDrowning Can Occur Hours After SwimmingClimate Change May Trigger 60,000 More Premature Deaths by 2030
Questions and AnswersLinksBook Reviews
Related Topics

Antiplatelet Bleeding Risk Higher Than Expected for Older Patients


HealthDay News
Updated: Jun 14th 2017

new article illustration

WEDNESDAY, June 14, 2017 (HealthDay News) -- Long-term daily aspirin use is linked to a higher-than-expected risk of disabling or fatal bleeding in patients aged 75 and over, according to a study published online June 13 in The Lancet.

Linxin Li, D.Phil., from the University of Oxford in the United Kingdom, and colleagues conducted a population-based cohort study involving patients with a first transient ischemic attack, ischemic stroke, or myocardial infarction treated with antiplatelet drugs (mostly aspirin) from 2002 to 2012, with follow-up to 2013.

The researchers found that during 13,509 patient-years of follow-up, 3,166 patients had 405 first bleeding events. There was no correlation for the risk of non-major bleeding with age; major bleeding increased with age (≥75 years: hazard ratio, 3.10), especially for fatal bleeding (hazard ratio, 5.53), which was sustained during follow-up. Similar trends were seen for major upper gastrointestinal bleeds (≥75 years: hazard ratio, 4.13), especially if the bleeding was disabling or fatal (hazard ratio, 10.26). To prevent one disabling or fatal upper gastrointestinal bleed over five years, the estimated number needed to treat (NNT) for routine proton pump inhibitor (PPI) use decreased from 338 for individuals younger than 65 years to 25 for individuals aged 85 years and older.

"Given that half of the major bleeds in patients aged 75 years or older were upper gastrointestinal, the estimated NNT for routine PPI use to prevent such bleeds is low, and co-prescription should be encouraged," the authors write.

One author disclosed financial ties to Bayer.

Abstract
Full Text
Editorial