Skip 
Navigation Link
Medical Disorders
Resources
Basic InformationLookupsLatest News
Family History Questionnaire Ups Genetic Counseling for CRCBlood Test Can Detect GLUT1 Deficiency SyndromeWallpaper May Breed Toxins: StudyFish Eaters Report Less Rheumatoid Arthritis PainGuided Exercise May Help Chronic Fatigue Patients: Study2006 to 2013 Saw Increase in ER Use for Herpes ZosterNearly 60 Percent With Conjunctivitis Fill Antibiotic RxTissue Testing Can Spot Zika at Birth: CDCGuidelines Address Peri-Op Care in Rheumatic DiseaseZika-Bearing Mosquitoes More Widespread in U.S. Than ExpectedMarital Status Among Factors Tied to Gout Rx AdherenceMany Chronic Illnesses Linked to Suicide RiskVaccine Curbs High Cholesterol in MiceStudy Hints at Link Between Some Statins, Parkinson's RiskHydrotherapy Plus Conventional Drugs Beneficial in RAChronic Lyme Disease Treatments Tied to Serious Adverse EffectsOlder Age Needn't Be a Barrier to Herniated Disc SurgeryNon-Opioid Drug More Effective for Migraines: StudyHealth Tip: Managing Arthritis FatigueCertain Criteria May Be Better Than Others in RA Assessment20 Percent of Hospital Patients Have Side Effects From Abx RxRecreational Activity-Linked Facial Fractures Up in SeniorsUnusual Measles Outbreak Described in Ontario in Early 2015Seniors Get Good Results From Herniated Disc Surgery'Good' Donor Bacteria Can Last Long Term in Stool Transplant PatientsNovel Retinal Lesion Seen in Some Ebola SurvivorsHealth Tip: Recognizing Summer Allergy SymptomsAre You at Risk for Metabolic Syndrome?Antiplatelet Bleeding Risk Higher Than Expected for Older PatientsVideo Call May Be as Good as Doctor Visit for HeadacheCould Prefab Blood Vessels Revolutionize Root Canals?A Sufferer's Guide to Easin' Sneezin' SeasonHospitals Get Good News About Fighting Staph InfectionsCases of Legionnaires' Disease Reported in NYC, Las VegasOlive Oil, Ibuprofen May Have Synergistic EffectsObesity Prevalence Has Doubled in More Than 70 CountriesSeveral New Medications in the Pipeline to Prevent MigraineReview: Depression Screening As Inpatient Important, FeasibleVitamin B6 Linked to Increased Risk of Hip Fracture2 Billion Worldwide Are Obese or OverweightPatient's Education Level May Be Key to Heart RiskMeds Rooted in Ancient China May Help Heart: ReviewBats Harbor Viruses That Could Cause Outbreaks in HumansExperimental Zika Vaccine Protects Mice Against Virus: StudyGlobal Climate Change Could Cause Rise in Airway IrritationEqual Wound Complications for Staples, Suture in Obese WomenDepression Can Slow Hospital Patients' Recovery: StudyEven Your Bones Can Get Fat, Mouse Study SuggestsNew Drugs Show Promise as First to Prevent Migraine1 in 7 Americans Has Kidney Disease: CDC
Questions and AnswersLinksBook Reviews
Related Topics

Positive Clinical Effects Seen for Placebos Without Deception


HealthDay News
Updated: Jun 6th 2017

new article illustration

TUESDAY, June 6, 2017 (HealthDay News) -- Open-label placebos are associated with a positive effect compared with no treatment in a variety of clinical conditions, according to a review and meta-analysis published online May 30 in the Journal of Evidence-Based Medicine.

James E.G. Charlesworth, Ph.D., from the University of Oxford in the United Kingdom, and colleagues conducted a systematic review and meta-analysis to examine the clinical efficacy of open-label placebos versus no treatment. Five trials with 260 participants met the inclusion criteria.

The clinical conditions included in the trials were irritable bowel syndrome, depression, allergic rhinitis, back pain, and attention-deficit/hyperactivity disorder. The researchers observed moderate risk of bias in the trials. There was a positive effect for non-deceptive placebos (standardized mean difference, 0.88; 95 percent confidence interval, 0.62 to 1.14; P < 0.00001).

"Open-label placebos appear to have positive clinical effects compared to no treatment," the authors write. "Caution is warranted when interpreting these results due the limited number of trials identified, lack of assessor blinding, and the fact that positive messages were included alongside open label placebos."

Abstract
Full Text (subscription or payment may be required)